William Mackwitz (February 21, 1831 - August 6, 1919) was a German-American engraver and lithographer active in St. Louis in the second half of the 19th century. Mackwitz was born in Braunschweig, Germany and emigrated to the United States in 1856 - settling in St. Louis. He worked as an engraver in St. Louis for roughly 60 years. A collection of Mackwitz notebooks and sketchbooks survive at the Missouri History Museum.

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